NRAS Q61R-mutant mucosal melanoma with cardiac metastasis - a diagnostic challenge
نویسندگان
چکیده
منابع مشابه
NRAS mutant melanoma – undrugable?
Mutations in the three rat sarcoma (RAS) family members NRAS (neuroblastoma-RAS), HRAS (Harvey-RAS) and KRAS (Kirsten-RAS) are found in one third of human cancers. Among the first oncogenes discovered in cutaneous melanoma was NRAS, which is mutant in up to 20% of tumors causing aberrant signaling in several downstream cascades. Despite, being a highly relevant therapeutic target, design of sma...
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Oral mucosal melanoma (OMM) is a fatal sarcoma of unknown etiology. Histological morphology and genetic events are distinct from those of its cutaneous counterpart. Mutation and up-regulation of c-kit has been identified in OMM which may activate downstream molecules such as RAS and RAF. These molecules are involved in the mitogen-activated protein kinase (MAPK) pathway leading to tremendous ce...
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ژورنال
عنوان ژورنال: MOJ Clinical & Medical Case Reports
سال: 2020
ISSN: 2381-179X
DOI: 10.15406/mojcr.2020.10.00365